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Scientist-ccmb/invitropharmacology

3 - 5 yrs
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Not Disclosed by Recruiter Openings: 1 Posted 5 days ago Job Applicants: 279 Job Views: 917

Job Description

 
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    1. Design and conduct experiments to identify and characterise novel biomolecules and compounds and novel targets with the potential to translate into innovative therapies.
    2. Be responsible for the development and execution of novel in vitro assays, and, where needed, their use in routine compound screening and profiling activities. The ability to troubleshoot issues with assay performance will be required.
    3. Be responsible for designing, developing and implementing cellular assays and models for the characterization of cellular phenotypes to support drug discovery and target validation efforts (i.e. compound mechanism of action, selectivity, context ID etc.).
    4. Independently define and execute best experimental strategies and lab operations to a) deliver interpretable data to test hypothesis, b) address scientific questions or technical problems and c) progress projects. Self-motivation and critical thinking are essential.
    5. Identify and implement new technologies and help to establish infrastructure (internal, external) to enable strategy implementation and execution.
    6. Work collaboratively with colleagues from Biology, Protein Sciences, Chemistry, and Bio-informatics and/or CROs to optimize compound selection and explore and validate the therapeutic potential of drug targets.

    7. Extensive experience in molecular biology techniques (isolation, processing and cultivation of primary cells/tumors, standard cloning procedures, nucleic acid extraction, RT-PCR, qPCR, Western Blot, ELISA-based methods, IHC, flow cytometry, fluorescence microscopy etc.).

    8. Experience in maintain cell culture lab.

    9. Experience in Cell biology based assays for oncology, inflammation markers by using different techniques like absorbance, fluorescence, luminescence, Fluorescence polarization, TRF, TR-FRET and alpha screen.

    10. Experience in MS office and GraphPad prism.

    11. Good knowledge of English (spoken and written).

    12. Provide datasets to progress early stage projects into pre-clinical development.
    13. Have the flexibility and ability to work on several projects simultaneously and to meet tight deadlines, as well as a desire to work in a high paced and collaborative team environment.

Salary: Not Disclosed by Recruiter

Industry: Pharma, Biotech, Clinical Research

Functional Area: Medical , Healthcare , R&D , Pharmaceuticals , Biotechnology

Role Category:R&D

Role:Clinical Research Associate/Scientist

Employment Type: Full Time, Permanent

Keyskills

Education-

UG: B.Pharma - Pharmacy

PG:M.Pharma - Pharmacy, MS/M.Sc(Science) - Biotechnology

Company Profile:

Ribosome Research Centre Pvt. Ltd.

Ribosome Research Centre Private Limited is a leading, Gujarat-based Contract Research Organization providing a wide range of chemistry, analytical and non clinical research services aimed to deliver to a spectrum of industries like Pharmaceuticals, Herbals, Bulk drugs, Chemicals, Agro-chemicals, Medical devices, Food and cosmetics manufacturers. The research facility has employed state-of-the-art facility across its landscape spread over 100,000 sq ft in an 8 acre campus.
Regulatory Services- General Toxicology, Mutagenicity, Toxico-kinetics, Immuno-toxicology, Inhalation Toxicology, Eco-toxicology, Developmental and reproductive Toxicology (DART), Biological Tests, Physico Chemical Testing, Impurity Profiling, Chemical/Drug Characterization, Drug Metabolism and Pharmacokinetic (DMPK), Safety pharmacology etc.
Drug Discovery & Development Services- Facility has cutting edge Drug Discovery and Development Labs to support array of functions like Custom synthesis, Medicinal chemistry, cell based assays, molecular biology, Pharmacokinetics, In-vivo pharmacology, Regulatory toxicology, Process R&D, Formulation and Analytical development, Analytical method development, Biopharmaceutical development, Process & product development, Nano-drug delivery system development, Protein and peptides delivery system, Bioavailability enhancement, Novel carriers for cancer targeting etc.
The thrust areas include lead Identification and screening, cell based assays, customized animal model development for a wide range of therapeutic areas like oncology (Xenograft, Syngenic, Orthotopic, Metastasis, angiogenesis), Metabolic Disorders, Pain and inflammation, Neuro-pharmacology, Endocrine disorders etc.
Pharmaceuticals Quality Control Testing- Analytical, Microbiological, Physico-chemical, in-vitro and in-vivo drugs testing as per pharmacopoeial standards.

Medical Devices- Biological evaluation of Medical devices as per ISO 10993.

Highly equipped Small animal vivarium complying at par with the requirements of CPCSEA and AAALACi, is having 50 animal housing rooms with dedicated once through AHU systems having 25 ACPH with double corridor layout attainable to ISO class 8.
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